Ultrasound to Detect Splenomegally in Patients With Isolated Thrombocytopenia

Assiut University

Status: Begins enrollment this month

Conditions: Amegakaryocytic Aplasia; Unilineage Myelodysplastic Syndrome ( Megakaryocyte Dysplasia); Primary Immune Thrombocytopenic Purpura; Lymphoproliferative Disorder With Secondary ITP; Autoimmune Diseases With Secondary ITP

Study type: Observational

Funder types: Other

Identifiers

NCT07182760

S.I.TH

Details and patient eligibility

About

Investigate prevalence of splenomegally in patients with isolated thrombocytopenia.

Asess effect of splenomegally in clinical picture ,Complication, treatment response and disease outcome To explain possible causes of splenomegally in patients with isolated thrombocytopenia

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients more than 18 years admitted with isolated thrombocytopenia due to primary Immune thrombocytopenic purpura amegakaryocytic aplasia Unilineage myelodysplastic syndrome ( megakaryocyte dysplasia) lymphoproliferative disorder with secondary ITP autoimmune diseases with secondary ITP Willingness to participate in the study Admitted patients or those who follow at hematology outpatients clinic

Exclusion criteria

EDTA induced pseudothrombocytopenia Platelet satellitism Drug induced thrombocytopenia Heparin induced thrombocytopenia / thrombosis syndrome post transfusion purpura Disseminated intravascular coagulopathy patients less than 18 years old patients with bicytopenia or pancytopenia Pregnancy

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Trial design

100 participants in 3 patient groups

Group 1a patients with isolated thrombocytopenia and splenomegaly

Description:

Group 1b patients with isolated thrombocytopenia without splenomegaly.

Group 1b patients with isolated thrombocytopenia without splenomegaly.

Description:

Group 1b patients with isolated thrombocytopenia without splenomegaly.

Group 2 healthy volunteers.