Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation

Norwegian University of Science and Technology

Status: Completed

Conditions: Atrial Fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT01493128

ABJ01

Details and patient eligibility

About

The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since current information is lacking on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF), it will be investigated whether a regulation of these proteins could be an underlying cause of the disease. Mitochondrial function will also studied.

1. The investigators hypothesize that both structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm.
2. The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm.

Enrollment: 45 patients

Sex: All

Ages: 50 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sinus rhythm, permanent atrial fibrillation or paroxysmal atrial fibrillation
• selected for open heart surgery
• informed consent

Exclusion criteria

• not given informed consent

Trial design

45 participants in 3 patient groups

stable sinus rhythm

permanent atrial fibrillation

paroxysmal atrial fibrillation