Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease

9

900 Hospital of the People's Liberation Army Joint Logistic Support Force

Status and phase

Completed
Phase 2
Phase 1

Conditions

Crohn Disease

Treatments

Drug: received hormone maintenance therapy
Other: UC-MSCs by peripheral intravenous infusion

Study type

Interventional

Funder types

Other

Identifiers

NCT02445547
UCMSC-CD

Details and patient eligibility

About

Stem cell transplantation has emerged as a relatively popular treatment that can help to regulate immunity, repair injury, and control inflammation. Several studies have used autologous stem cells or adipose-derived stem cells to treat Crohn's disease and its associated complications, and have achieved good efficacy. Thus far, the use of umbilical cord mesenchymal stem cells (UC-MSCs) to treat Crohn's disease has rarely been reported. In this study, UC-MSCs were used to treat patients with hormone-controlled Crohn's disease. We observed the disease control conditions, corticosteroid dosage changes, and treatment-related adverse reactions.

Enrollment

82 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • above 18 years of age
  • moderate to severe Crohn's disease (Crohn's disease activity index (CDAI) between 220 and 450)
  • had received hormone maintenance therapy for more than 6 months

Exclusion criteria

  • active tuberculosis
  • malignancy
  • HIV
  • syphilis
  • hepatitis B
  • hepatitis C

Trial design

82 participants in 2 patient groups

UC-MSCs
Experimental group
Description:
UC-MSCs by peripheral intravenous infusion
Treatment:
Other: UC-MSCs by peripheral intravenous infusion
control
Active Comparator group
Description:
received hormone maintenance therapy
Treatment:
Drug: received hormone maintenance therapy

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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