Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics (Alberta HEART)

University of Alberta

Status: Completed

Conditions: Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT02052804

AHFMRITG200801018

Details and patient eligibility

About

The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate the clinical, cellular and molecular mechanisms involved with the development and progression of HFpEF; 4) to design and test new therapeutic strategies for patients with HFpEF.

Enrollment: 700 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Group 1 No clinically overt heart failure
• Group 2 Known coronary artery disease
• Group 3 Known heart failure with preserved ejection fraction
• Group 4 Known heart failure with reduced ejection fraction
• Group 5 Healthy age-matched controls

Exclusion criteria

• Age <18 years
• Known malignancy with expected survival <1 year
• Pregnant or recent pregnancy <6 months
• Recent event (<2 weeks since Acute Coronary Syndrome, Heart failure or other admission
• Severe mitral or aortic stenosis