Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection

Trinidad and Tobago IVF and Fertility Centre

Status: Completed

Conditions: Zika Virus

Treatments: Other: Semen analysis and semen PCR for Zika virus

Study type: Observational

Funder types: Other

Identifiers

NCT02979938

ZIKAFERTI

Details and patient eligibility

About

In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection. These subjects will be followed up for a maximum of 12 months to observe the presence, viral load and infectivity of Zika virus (ZIKV) in semen over time.

Full description

In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection. These subjects will be followed up for a maximum of 12 months to observe the presence, viral load and infectivity of Zika virus (ZIKV) in semen over time.

Knowledge of the possible presence, infectivity and persistence of ZIKV in semen will provide evidence-based data for

1. estimating of the risk of sexual transmission of ZIKV in the general population
2. antenatal guidelines for the prevention of sexual transmission of ZIKV to the fetus
3. advising couples on the length of time that pregnancy should be avoided in women wishing to conceive after their partner's ZIKV infection
4. strategies to prevent transmission of ZIKV infection through assisted reproductive treatment (ART)
5. advice on gamete cryopreservation
6. optimising investigations for diagnosis of ZIKV in males.

Enrollment: 25 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male aged 18-50 years
• ZIKV symptoms within the preceding thirty days
• Confirmed ZIKV infection (WHO criteria)
• Able to ejaculate to produce a semen sample

Exclusion criteria

• Current urological malignancy