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Understanding Hallucinations (Part I) (UH-1)

U

UMC Utrecht

Status

Unknown

Conditions

No Hallucinations
Hallucinations

Study type

Observational

Funder types

Other

Identifiers

NCT01907568
UH-1
NL42959.041.13 (Other Identifier)

Details and patient eligibility

About

Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population. Effective treatment strategies for these symptoms in all patients are lacking and treatment-response can presently not be predicted. To date, the exact pathophysiological mechanism of these symptoms remains unknown. By investigating (subtypes) of hallucinations and delusions in all populations, a common pathway may be found, leading to more effective treatment options. Alternatively, different subtypes may be associated with different pathophysiological mechanisms.

Enrollment

700 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • age > 18 years
  • mentally competent
  • in case of delirium: family member able to give informed consent
  • Individuals with hallucinations will have to experience at least one episode of hallucinations over the last month.
  • Individuals without hallucinations: no current hallucinations and a history of maximum 1 episode of hallucinations with a maximum duration of 1 week, at least two years ago.

Exclusion criteria

  • Age <18)
  • Participants that cannot read, speak or understand Dutch
  • For all included diagnostic groups except delirium: Mentally incompetent individuals who are not capable to provide informed consent, as determined by their treating physician.

Trial design

700 participants in 11 patient groups

Patients with schizophrenia
Description:
With and without hallucinations
Patients with borderline personality disorder
Description:
With and without hallucinations
Patients with hearing impairment
Description:
With and without hallucinations
Patients with visual loss
Description:
With and without hallucinations
Patients with Parkinson's Disease
Description:
With and without hallucinations
Patients with Alzheimer's Disease
Description:
With and without hallucinations
Patients with dementia with Lewy Bodies
Description:
With and without hallucinations
Patients with Posttraumatic Stress Disorder
Description:
With and without hallucinations
Patients with delirium
Description:
With and without hallucinations
Healthy participants
Description:
With and without hallucinations
Patients with mood disorder
Description:
With and without hallucinations

Trial contacts and locations

4

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Central trial contact

Mascha M.J. Linszen, MD; Sophie M. Heringa, PhD

Data sourced from clinicaltrials.gov

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