Understanding Immunity Persistence After Adolescent MenC Vaccination

University of Oxford

Status: Completed

Conditions: Antibody Persistance After Booster Dose of Men C Vaccine

Treatments: Other: Venepuncture and blood sample collection.

Study type: Observational

Funder types: Other

Identifiers

NCT01459432

OVG 2011/03

Details and patient eligibility

About

The main purpose of this study is to evaluate the duration of immunity after a booster dose of a MenC-CRM vaccine given to adolescents between 13 and 15 years of age. Does seroprotection persist beyond teenage years and into the early twenties? This is the age group which is most likely to carry the organism and to transmit it to other members of the population. If a booster dose of MenC vaccine given to adolescents does produce protective levels of antibody which persist into early adulthood, this would strengthen the case for such a booster to be added to the UK routine immunisation schedule, to reduce the risk of a resurgence of the disease in the future.

Enrollment: 134 patients

Sex: All

Ages: 20 to 23 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participants who completed clinical study M14P2E1
• Participant who are willing to participate and who would be expected to comply with the requirements of the protocol
• Participants who have given informed consent for participation in the study

Exclusion criteria

• History of invasive meningococcal C disease (or any case of invasive meningococcal disease where the serotype was unknown)
• Confirmed or suspected immunosuppressive or immunodeficient conditions, including human immunodeficiency virus (HIV) infection
• Severe blood clotting disorders

Trial design

134 participants in 1 patient group

Follow-on blood sample from previous study

Treatment:

Other: Venepuncture and blood sample collection.