Understanding New Semantic Memory Learnings Across the Lifespan (ULIS)

Caen University Hospital

Status: Not yet enrolling

Conditions: Neurodevelopmental Changes (Childhood, Ageing)

Treatments: Device: Electroencephalography

Study type: Observational

Funder types: Other

Identifiers

NCT06442670

2024-A00167-40

Details and patient eligibility

About

The aim of this research is to specify the changes in brain connectivity (i.e. EEG phase synchronisation between brain regions) associated with semantic learning between individuals belonging to different age groups.

Full description

Semantic memory is a crucial concept in cognitive science. It has long been conceptualised as a static, amodal memory system containing knowledge about the world, concepts and symbols. Although recourse to this concept is inevitable, the mechanisms, both cognitive and neurobiological, that govern it are far from being elucidated. There are many debates and controversies in this fundamental field of cognitive science, and more specifically around the question of the acquisition and formation of knowledge in semantic memory. The literature on the development of semantic memory during ontogeny is full of contradictions.

A review of this literature highlights the many unanswered questions surrounding semantic memory. How quickly is information encoded and then consolidated into a format that justifies the term semantic knowledge? What are the neural bases underlying the formation of knowledge in semantic memory? How does semantic knowledge evolve through new episodes? How do these mechanisms evolve during ontogeny? To what extent can some semantic learning be preserved from cognitive ageing? In the face of these many questions, the literature highlights the lack of tasks enabling semantic memory to be approached in an operational manner and the need to specify the cerebral mechanisms involved at different ages of life.

The general hypotheses that will be tested as part of the ULIS project are as follows:

1. New semantic learning is possible independently of episodic memory processes.
2. This learning differs according to the age of the participants.

Enrollment: 200 estimated patients

Sex: All

Ages: 6 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non-opposition by the participant or those exercising parental authority in the case of minors
• French language fluency (assessed by the investigating team)
• Absence of global cognitive deficit attested by a score on the MOCA (Montreal Cognitive Assessment) scale greater than or equal to 26/30 (test carried out at inclusion).

Exclusion criteria

• Person subject to a guardianship, curatorship or safeguard of justice measure
• Non affiliation to a social security scheme

Trial design

200 participants in 5 patient groups

6-7 years children

Treatment:

Device: Electroencephalography

10-11 years children

Treatment:

Device: Electroencephalography

20-35 years adults

Treatment:

Device: Electroencephalography

60-70 older adults

Treatment:

Device: Electroencephalography

70-80 older adults

Treatment:

Device: Electroencephalography