Unexcitability Along the Ablation as an Endpoint for Atrial Fibrillation Ablation

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Paroxysmal Atrial Fibrillation; Catheter Ablation Strategies

Treatments: Device: catheter based pulmonary vein isolation

Study type: Interventional

Funder types: Other

Identifiers

NCT01724437

PV3503

Details and patient eligibility

About

to assess the near-term (12 months) efficacy of pulmonary vein isolation.

Full description

The aim of the study was to assess the near-term (12 months) efficacy of pulmonary vein isolation using a standard approach compared to application of an additional acute procedural endpoint of unexcitability along the ablation line.

Enrollment: 102 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• written informed consent
• age > 18 years
• paroxysmal atrial fibrillation

Exclusion criteria

• structural heart disease
• intracardiac thrombus
• reversible causes of atrial fibrillation
• inability to take warfarin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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102 participants in 2 patient groups

Loss of pace capture

Active Comparator group

Description:

Pulmonary vein isolation: Ablation along the ablation line is continued until loss of pace capture along the ablation line is achieved catheter based pulmonary vein isolation

Treatment:

Device: catheter based pulmonary vein isolation

Conventional

Active Comparator group

Description:

Pulmonary vein isolation: Ablation is discontinued when electrical isolation of the pulmonary veins is achieved. catheter based pulmonary vein isolation

Treatment:

Device: catheter based pulmonary vein isolation