Uniformity of Oral Contrast Material in the Bowel

University of California San Francisco (UCSF)

Status: Completed

Conditions: Known or Suspected Abdominal Disease

Treatments: Drug: Diatrizoate; Drug: Barium; Drug: Iohexol

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02542046

15-16964

Details and patient eligibility

About

Although positive oral contrast agents are used for the majority of abdominopelvic CT scans in the United States, the quality of bowel opacification has not been compared between the three major classes of positive oral contrast material (barium sulfate, ionic iodinated contrast material, and non-ionic iodinate contrast material). This is a retrospective single institution study of clinical records to show whether the uniformity of bowel opacification is different between the three main types of positive CT oral contrast material used in the United States (Barium sulfate, Diatrizoate, and Iohexol). The investigators will retrospectively identify 250 patients each who received oral barium sulfate, diatrizoate, and iohexol for CT scanning of the abdomen and pelvis (total 750 patients) and assess the quality of bowel lumen opacification by the positive oral contrast agents.

Full description

Although positive oral contrast agents are used for the majority of abdominopelvic CT scans in the United States, the quality of bowel opacification has not been compared between the three major classes of positive oral contrast material (barium sulfate, ionic iodinated contrast material, and non-ionic iodinate contrast material). The investigators will retrospectively identify 250 patients each who received oral barium sulfate, diatrizoate, and iohexol for CT scanning of the abdomen and pelvis (total 750 patients) and assess the quality of bowel lumen opacification by the positive oral contrast agents.

Primary objective:

• To show the uniformity of bowel opacification is different between the three main types of CT oral contrast material used in the United States (Barium sulfate, Diatrizoate, and Iohexol).

Secondary objectives:

• To show whether or not one of the oral contrast agents provides more uniform opacification than the others in the proximal or distal bowel
• To assess the relative opacification of the distal small bowel (ileum) by the three contrast agents.

Enrollment: 900 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CT scans in which oral contrast material was given

Exclusion criteria

• CT scans in which an obvious paucity of oral contrast material is seen,
• CT scans of patients who had studies within 1 week prior where enteric contrast may have been given, including fluoroscopic, endoscopic, or interventional studies

Trial design

900 participants in 3 patient groups

Barium

Description:

Patients who received barium sulfate oral contrast for abdominopelvic CT

Treatment:

Drug: Barium

diatrizoate

Description:

Patients who received diatrizoate oral contrast for abdominopelvic CT

Treatment:

Drug: Diatrizoate

iohexol

Description:

Patients who received iohexol oral contrast for abdominopelvic CT

Treatment:

Drug: Iohexol