Universal- Versus Guidelines-Directed Genetic Testing for Germline Pathogenic Variants Utilizing a Multi-Gene Panel for Inherited Cancers in Non-Western Society.

King Hussein Cancer Center

Status: Completed

Conditions: Genetic Predisposition

Study type: Observational

Funder types: Other

Identifiers

NCT04920513

21 KHCC 27

Details and patient eligibility

About

The investigators aim to study the pattern and frequency of pathogenic variants among ALL newly diagnosed cancer patients in a genetically distinct population.

Additionally, the investigators will study the uptake rate of "cascade family screening", frequency of pathogenic variants and barriers against testing.

Enrollment: 3,000 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient, age ≥ 18 years at time of cancer diagnosis
• Pathology proven diagnosis of cancer; any site, any stage (prior history of cancer is allowed)
• Jordanian nationality
• Willingness to participate
• Signed consent form

Exclusion criteria

• Major psychiatric disorder (defined as: patients followed by a psychiatrist and on antipsychotic medications)
• Non-Jordanian
• Patients with Leukemia, Lymphoma and Myeloma