Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases

Mayo Clinic

Status: Completed

Conditions: Cardiopulmonary Disease

Treatments: Other: Echocardiography; Other: Pulmonary Gas Exchange

Study type: Interventional

Funder types: Other

Identifiers

NCT03911856

19-000626

Details and patient eligibility

About

Researchers are trying to develop innovative strategies that target the early identification heart and lung imbalances in patients with cardiopulmonary diseases.

Enrollment: 7 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy controls (no known cardiac or pulmonary disease);
• PAH/HFpEF patients with known RV failure;
• PAH/HFpEF patients with known pulmonary failure
• Newly diagnosed PAH/HFpEF patients without any evidence of profound RV or pulmonary dysfunction.

Exclusion criteria

• Persons unable to perform light exercise
• Persons pregnant or planning to be pregnant

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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7 participants in 2 patient groups

Non-invasive assesment techniques

Experimental group

Description:

We hypothesize that non-invasive indices of right ventricular RV (echocardiograph-derived strain and strain rate) and pulmonary (gas exchange-derived lung diffusion and surface area) function during light exercise will successfully identify and discern patients with known RV dysfunction pulmonary arterial hypertension and heart failure with preserved ejection fraction(PAH/HFpEF with RV failure) from those with known pulmonary dysfunction (PAH/HFpEF with pulmonary fibrosis). Additionally, we hypothesize that our assessment techniques will identify subtle derangements in RV and pulmonary function in newly diagnosed PAH and HFpEF patients, and that this may guide early and targeted therapeutic intervention.

Treatment:

Other: Echocardiography

Other: Pulmonary Gas Exchange

Efficacy of acute-oxygen therapy during exercise

Experimental group

Description:

We hypothesize that breathing hyperoxia will increase exercise capacity by reversing RV and pulmonary derangements, and that the mechanisms of action will be related to the underlying dysfunction (e.g., reducing pulse volume recording PVR, increasing RV functional reserve, increasing gas diffusion).

Treatment:

Other: Echocardiography

Other: Pulmonary Gas Exchange