Unravelling The Optimisation And Consolidation Of Motor Skills In People With Multiple Sclerosis With Mild to Moderate Gait Impairment: A Feasibility Study (UNLOCK MS MGI)

University Hospital of Ferrara

Status: Enrolling

Conditions: Multiple Sclerosis

Treatments: Behavioral: High Intensity Task Oriented Circuit Training + Telerehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT07058870

UNLOCK_MS_MGI_HITOCT

Details and patient eligibility

About

The goal of this feasibility study is to test the safety and effectiveness of an high-intensity task oriented circuit training program, followed by three months of telerehabilitation in people with mild to moderate Multiple Sclerosis (MS). The main questions it aims to answer are:

• Can high-intensity task oriented circuit training improve gait and balance functional capacity?
• Can telerehabilitation mantain the benefits in gait and balance gained via circuit training for a six month period?

Participants will:

• Complete 10 session ( one hour each, three times a week) of high-intensity task oriented circuit training administered in a hospital setting. The training will target key motor skills such as walking, stepping, supine to stand transitions and general mobility.
• Engage in 3 months of asynchronous telerehabilitation (without physiotherapist supervision)

Enrollment: 18 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of primary or secondary progressive multiple sclerosis according to the McDonald criteria.
• Mini-Mental State Examination (MMSE) score > 24.
• Expanded Disability Status Scale (EDSS) score ≤ 6.

Exclusion criteria

• Presence of other psychiatric or neurological disorders.
• Cardiopulmonary, renal, or liver diseases.
• Pregnancy.
• Modifications in drug treatment within the last 3 months.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Experimental: High Intensity Task Oriented Circuit Training + Telerehabilitation

Experimental group

Description:

Participants will receive 10 sessions (one hour each, three times a week) including structured exercise stations targeting key motor skills such as walking, walking adaptability, stepping and supine to stand transition. Afterwards, participants will engage in 36 sessions (30 minutes each, three times a week) of asynchronous telerehabilitation targeting supine to stand transition, stepping and walking.

Treatment:

Behavioral: High Intensity Task Oriented Circuit Training + Telerehabilitation