UPDRS-III Comparisons of DBS for PD Between Patients Receiving MAC and AAA Anesthesia

Shenzhen University

Status: Completed

Conditions: Parkinson Disease; Anesthesia

Treatments: Procedure: AAA anesthesia; Procedure: MAC anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT04361188

FS20191119007

Details and patient eligibility

About

Compares the patients' scores of UPDRS-III before and six-month after receiving deep brain stimulation for Parkinson's disease under MAC or AAA anesthesia.

Full description

Compares the patients' scores of UPDRS-III before and six-month after receiving deep brain stimulation for Parkinson's disease under MAC or AAA anesthesia. Besides, the research also compares the adverse events, LED, dosage of anesthetic drugs, wake-up time, surgical time, Hoehn&Yahr, PQD-39, MMSE, MoCA, HAMA, HAMD and patients' satisfaction between the two groups mentioned above.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age greater than 18 years old
• Diagnosis of primary Parkinson's disease
• Parkinson's disease-related symptoms remain difficult to control with appropriate anti-parkinsonian medications.

Exclusion criteria

• Refusal to Participate in the research
• Patients with severe comorbidities such as severe sleep apnea syndrome and metal disorder
• Previous functional neurosurgery: DBS, thalamic incision, etc.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups

MAC anesthesia group

Experimental group

Description:

Parkinson's disease patients receiving deep brain stimulation under MAC anesthesia.

Treatment:

Procedure: MAC anesthesia

AAA anesthesia group

Active Comparator group

Description:

Parkinson's disease patients receiving deep brain stimulation under AAA anesthesia.

Treatment:

Procedure: AAA anesthesia