Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

Mayo Clinic

Status: Not yet enrolling

Conditions: Obesity

Treatments: Diagnostic Test: Meal Study

Study type: Interventional

Funder types: Other

Identifiers

NCT07031297

24-007465

Details and patient eligibility

About

The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All women must be premenopausal

Exclusion criteria

• Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
• Diabetes, history of cardiovascular disease
• Allergy to lidocaine
• Post-menopausal women
• Pregnant

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Normal weight group

Other group

Description:

5 male and 5 female volunteers in normal weight range

Treatment:

Diagnostic Test: Meal Study

Obesity group

Other group

Description:

5 male and 5 female volunteers with obesity (BMI 29.0-35.0 kg/m2)

Treatment:

Diagnostic Test: Meal Study