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Upper Extremity Functional Skills in Patients With Parkinson Disease (pwPD)

K

Kahramanmaraş Sütçü İmam University (KSU)

Status

Completed

Conditions

Muscle Strength Development
Functional Skills
Upper Extremity
PARKINSON DISEASE (Disorder)

Study type

Observational

Funder types

Other

Identifiers

NCT07180004
Parkinson

Details and patient eligibility

About

Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized pathologically by the progressive loss of dopaminergic neurons in the substantia nigra and clinically by the presence of motor symptoms such as bradykinesia, resting tremor, and/or rigidity.Patients with Parkinson's disease (pwPD) often exhibit poor manual dexterity and decreased strength. Fine motor deficits seen in PD include an inability to control cognitive power/force, poor manual dexterity, and motor dysfunction, which includes difficulties achieving the angles, speed, and coordination required for basic movements. Anatomical strength, as detailed in activities of daily living (ADL), is an important indicator of motor characteristics and vitality.Studies have shown a strong relationship between postural control and fine motor functions. For high-quality distal movement, better proximal stabilization is necessary. During upper extremity functions, the body's center of gravity must shift with arm movements, allowing adaptation to changing gravity. Good trunk control is essential in this dynamic process of maintaining balance. Studies examining this link between trunk control, balance, and hand functions are available in the literature. Among these studies conducted in diverse populations, studies involving PD are very few. Investigating parameters such as grip strength, upper extremity dexterity, and reaction time in PD will fill the gap in the literature. Meta-analysis studies have shown that muscle strength and strength in individuals with PD are lower than in healthy individuals. Furthermore, muscle strength in PD has been shown to be related to functional capacity and disease severity. In light of all this information, our study was designed to investigate the relationship between upper body muscle strength, particularly proximal and distal, and manual dexterity in PD. In this direction, the aim of this study is to determine the relationship between proximal and distal muscle strength and upper extremity functional abilities in PD.

Enrollment

70 patients

Sex

All

Ages

40 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy individuals aged 40-75 years, diagnosed with idiopathic PD according to the UK Parkinson's Disease Association Brain Bank criteria by a specialist neurologist, with a Modified Hoehn & Yahr (m-HY) scale stage ≤4, and with a Mini Mental State Examination score of ≥22 for those with training and ≥18 for those without training, and with no known disease, volunteered to participate in the study.
  • Individuals with no other known neurological and/or systemic disease
  • Individuals without any upper extremity contractures

Exclusion criteria

  • Individuals with diagnosed and/or treated psychiatric illnesses who are considered unable to complete the tests.
  • Those taking neuroleptic medications or antidepressants.
  • Individuals with orthopedic conditions that interfere with manual dexterity tests, such as severe dyskinesia, carpal tunnel syndrome, tendon injuries, or finger amputations; rheumatological conditions such as rheumatoid arthritis and osteoarthritis; and individuals with any neurological condition other than PD.

Trial design

70 participants in 2 patient groups

1/study group
Description:
Individuals between the ages of 40 and 75 diagnosed with idiopathic Parkinson's disease (n=40)
2/control group
Description:
Healthy individuals between the ages of 40-75 (n=30)

Trial contacts and locations

2

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Central trial contact

hatice adıgüzel tat, Associate Proffessor

Data sourced from clinicaltrials.gov

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