Uppsala-Dalarna Dementia and Gait Project (UDDGait™)

Dalarna University

Status: Enrolling

Conditions: Dementia of Alzheimer Type; Mild Cognitive Impairment; Subjective Cognitive Impairment; Dementia Senile; Dementia; Dementia, Mixed

Treatments: Diagnostic Test: Timed Up-and-Go dual-task (TUGdt); Diagnostic Test: Timed Up-and-Go (TUG single-task); Diagnostic Test: Clinical functional assessment

Study type: Observational

Funder types: Other

Identifiers

NCT05893524

PUBCARE2016_122 (Other Identifier)

HDA2021-00022

Details and patient eligibility

About

UDDGait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom relieving and health promoting interventions.

A new concept is investigated for this purpose: a "dual-task-test", which implies the combination of a well-established mobility test (Timed Up-and-Go, TUG) with a simultaneous verbal task (i.e. TUG dual-task, TUGdt). This type of test has been judged as a potential aid for early identification of dementia disease. More research is needed to further examine the test's validity, reliability and predictive capacity.

The overall aim is to investigate if TUGdt is useful as an aid for prediction of dementia disease. To ensure the results, the aim is also to evaluate the test's measurement properties and to generate normative reference values of healthy control persons.

Enrollment: 550 estimated patients

Sex: All

Ages: 37 to 94 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing memory assessment at at Uppsala University Hospital, Sweden
• Patients undergoing memory assessment at at Falu Hospital, Sweden
• Cognitively unimpaired individuals with a Mini Mental State Examination (MMSE) score of > 26

Exclusion criteria

• Inability to walk three meters back and forth
• Inability to rise from a sitting position
• Indoor use of a walking aid
• Current or recent hospitalization (within the last 2 weeks)
• Need of an interpreter to communicate in Swedish

Trial design

550 participants in 4 patient groups

Patients undergoing memory assessments

Description:

Patients undergoing memory assessments at two specialist memory clinics (Uppsala University Hospital in Uppsala and Falu Hospital in Falun). This group includes patients with dementia, mild cognitive impairment and subjective cognitive impairment.

Treatment:

Diagnostic Test: Clinical functional assessment

Diagnostic Test: Timed Up-and-Go (TUG single-task)

Diagnostic Test: Timed Up-and-Go dual-task (TUGdt)

Cognitively unimpaired community dwelling people

Description:

Age matched cognitively unimpaired community dwelling people recruited via advertisements.

Treatment:

Diagnostic Test: Clinical functional assessment

Diagnostic Test: Timed Up-and-Go (TUG single-task)

Diagnostic Test: Timed Up-and-Go dual-task (TUGdt)

Cognitively unimpaired community dwelling people recruited for test-retest reliability analysis

Description:

Cognitively unimpaired individuals who agreed to participate in a retesting session.

Treatment:

Diagnostic Test: Clinical functional assessment

Diagnostic Test: Timed Up-and-Go (TUG single-task)

Diagnostic Test: Timed Up-and-Go dual-task (TUGdt)

Persons with cognitive impairment recruited for test-retest reliability analysis

Description:

Patients undergoing memory assessment at Uppsala University Hospital who agreed to participate in a retesting session and community dwelling older persons with self-reported subjective or mild cognitive impairment. This group includes patients with dementia, mild cognitive impairment and subjective cognitive impairment.

Treatment:

Diagnostic Test: Clinical functional assessment

Diagnostic Test: Timed Up-and-Go (TUG single-task)

Diagnostic Test: Timed Up-and-Go dual-task (TUGdt)