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Uptake and Utilization of Amino Acids by Splanchnic Bed

T

The Hospital for Sick Children

Status and phase

Completed
Phase 1

Conditions

Healthy Males

Treatments

Other: Threonine Experimental: Study Period 1
Other: Lysine Experimental: Study Period 2

Study type

Interventional

Funder types

Other

Identifiers

NCT01032616
0019880597 (Part b)

Details and patient eligibility

About

Splanchnic uptake and metabolism contributes significantly to the differences in flux seen between the intravenous and intragastric ingestion of certain indispensable amino acids.

This is the third in a series of studies designed to increase the investigators knowledge of the metabolism of two indispensable amino acids, threonine and lysine, by the splanchnic bed. In the initial two studies the investigators established the neonatal parenteral requirement of threonine and lysine. In the current study, the investigators will be examining the differences in uptake and metabolism of threonine and lysine across the splanchnic bed.

Full description

We propose that we will see a smaller amount of enterally fed isotopes reach the plasma as compared to the amount in plasma from the parenterally delivered isotopes. We also believe that the amount of enterally delivered threonine isotope that reaches the plasma will be significantly less than the amount of enterally fed lysine isotope.

Enrollment

6 patients

Sex

Male

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy Males

Exclusion criteria

  • History of inborn error of metabolism
  • Presence of a chronic disease
  • Have unusual dietary practices
  • Has recently lost weight
  • Receiving pharmacological therapy or hormonal treatment

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

6 participants in 2 patient groups

Study Period 1
Experimental group
Description:
AA given by parenteral and enteral routes with tracer 1-13C phenylalanine given to observe differences
Treatment:
Other: Threonine Experimental: Study Period 1
Study Period 2
Experimental group
Description:
AA given by parenteral and enteral routes with tracer 1-13C phenylalanine given to observe differences
Treatment:
Other: Lysine Experimental: Study Period 2

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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