Uremic Toxin Removal and Hemodynamics in Long-hour Hemodialysis and Hemodiafiltration
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About
Rationale: The mortality of end-stage renal disease (ESRD) patients on dialysis remains high. This may at least be partly due to the insufficient removal of (especially protein-bound) uremic toxins which have been associated with cardiovascular morbidity and mortality. It is unknown whether the combination of long-hour haemodialysis (HD) with convection increases the removal of these toxins. Long-hour HD and long-hour haemodiafiltration (HDF) may also improve haemodynamic stability which is an important factor in treatment quality. The investigators aim to study the removal of uremic toxins in long-hour HD and HDF and to compare the haemodynamics between 4-hour and 8-hour HD and HDF.
Objectives: The primary aim is to study the removal of (especially protein-bound) uremic toxins in 4-hour and 8-hour HD and HDF. A secondary aim is to compare the haemodynamic response between 4-hour and 8-hour HD and HDF.
Enrollment
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Inclusion criteria
- prevalent conventional HD patients
- AV-fistula enabling double-needle vascular access with blood flow rate of at least 350 ml/min
- informed consent
- age more than 18 years
Exclusion criteria
- withdrawal of consent
- acute intercurrent illness (infection, malignancy, cardiovascular event, uncontrolled diabetes)
Trial design
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Allocation
Interventional model
Masking
20 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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