Urethral Stricture: A Comparison Between Jugal or Labial Graft Urethroplasty

Hospital de Clinicas de Porto Alegre

Status: Completed

Conditions: Urethral Stricture

Treatments: Procedure: Jugal Graft; Procedure: Labial Graft

Study type: Interventional

Funder types: Other

Identifiers

NCT03973619

170319

Details and patient eligibility

About

Buccal mucosa urethroplasty is a current fashion in urethral stricture management. In our university centre (Hospital de Clínicas de Porto Alegre) is a common surgical treatment choice. This paper aims to evaluate the success rate of this treatment after randomized choice between labial and jugal (inner cheek) grafts during the past two years.

Full description

Free dorsal graft urethroplasty, first described by Barbagli et al, has been shown better results than ventral grafts. Fixed grafts on the corpora cavernosa results in a better mechanical support and vascular supply, with less chance to complications such as pseudodiverticula and sacculations either a better urethral phisiology.

This study aims to evaluate the current surgical management in our centre: buccal mucosa graft urethroplasty with jugal or labial replacement, comparing their group success rate and complications between the groups in patients led to surgery from October 2016 to June 2018.

Prospective analysis from urethral stricture surgical HCPA patient data by dorsal buccal mucosa graft urethroplasty. The graft choice were done by a software. Longer stricture with transoperative need for the two grafts use were excluded. Success rate were measured with a no stricture de novo or absence of complications in a six month interval.

Enrollment: 77 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• Urethral Stricture Diagnosis
• Indication for buccal mucosa graft urethroplasty
• Accept the Informed Consent Term (patient or responsible)

Exclusion criteria

• Severe urethral stricture which a two-staged procedure are required
• Long strictures which need a both types of buccal mucosa graft due its length.
• Refuse to ICT for the patient ou it responsible

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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77 participants in 2 patient groups

Labial

Active Comparator group

Description:

Patients who received a labial graft as replacement of urethral tissue

Treatment:

Procedure: Labial Graft

Jugal

Active Comparator group

Description:

Patients who received a jugal (inner cheek) graft as replacement of urethral tissue

Treatment:

Procedure: Jugal Graft