Uric Acid Levels and Endothelial Functions

Mayo Clinic

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Other: Questionnaire of overall health

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02862522

05-004191

R01HL092954 (U.S. NIH Grant/Contract)

R01AG031750 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined. The aim of this study was to determine the relationship of serum uric acid, inflammatory markers and CED.

Enrollment: 229 patients

Sex: Female

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Referred to Mayo Clinic for cardiac catheterization
• Postmenopausal

Exclusion criteria

• History of percutaneous coronary intervention
• Coronary artery bypass graft surgery
• Unstable angina pectoris
• Valvular heart disease
• Peripheral vascular disease
• Known congestive heart failure

Trial design

229 participants in 2 patient groups

Women With CED

Description:

All subjects had blood work with included measurement of C-reactive protein, complete blood count with differential, basic chemistry panel, and uric acid level. All subjects completed a standardized questionnaire to assess baseline characteristics. All subjects underwent comprehensive coronary endothelial function assessment. Subjects completed a questionnaire of overall health several years after the index coronary angiogram and endothelial function study.

Treatment:

Other: Questionnaire of overall health

Women Without CED

Description:

All subjects had blood work with included measurement of C-reactive protein, complete blood count with differential, basic chemistry panel, and uric acid level. All subjects completed a standardized questionnaire to assess baseline characteristics. All subjects underwent comprehensive coronary endothelial function assessment. Subjects completed a questionnaire of overall health several years after the index coronary angiogram and endothelial function study.

Treatment:

Other: Questionnaire of overall health