Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis

University of Aarhus

Status: Completed

Conditions: Ureteral Obstruction

Study type: Observational

Funder types: Other

Identifiers

NCT00568724

MGM-01

Details and patient eligibility

About

The purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (UUO) and to elucidate the pathophysiology of UUO.

Enrollment: 45 patients

Sex: All

Ages: 3 months to 15 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction.
• Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain.

Exclusion criteria

• Bilateral hydronephrosis
• Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs.
• Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections < 6 months.
• Neurogenic bladder dysfunction.
• GFR < 40 % standardized to age.
• Non-compliance. Linguistic difficulties.

Trial design

45 participants in 4 patient groups

1

Description:

Children referred to surgical treatment of congenital hydronephrosis

2

Description:

15 age- and sex-matched controls

Children with healthy pelvic tissue

Description:

Children referred to nephrectomy due to nephrotic syndrome

Adults with healthy pelvic tissue

Description:

Adults referred to nephrectomy due to another cause than hydronephrosis