Urinary Creatinin/Protein Ratio in Preterms (PROTI-PREMA)

Centre Hospitalier Universitaire de la Réunion

Status: Completed

Conditions: Renal Failure; Preterm Infant

Study type: Observational

Funder types: Other

Identifiers

NCT04608279

2017/CHU/09

Details and patient eligibility

About

From the first days of life, the newborn presents a "physiological" proteinuria explained by the coexistence of a glomerular and tubular immaturity, all the more marked as the gestational age (GA) is weak. In the child term, proteinuria decreases the first month and its persistence is the marker of kidney damage. The persistence of proteinuria in preterm infants is also considered a marker of renal impairment; however, neither the "physiological" values nor the pattern of urinary excretion of proteins in the first month of life are known.

The proteinuria / creatininuria ratio is a validated indicator of proteinuria, as it is correlated with 24-hour urine proteinuria.

Enrollment: 124 patients

Sex: All

Ages: 1 to 2 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Premature gestational age at birth superior or equal to 32 week of amenorrhea hospitalized in the intensive care unit or neonatal intensive care unit of the University Hospital of Reunion, southern site, Saint Pierre, in the first 24 hours of life
• Informed consent form Legal representant

Exclusion criteria

• Renal malformation known in antenatal