Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Kidney Scarring Post-Febrile UTI

Study type: Observational

Funder types: Other

Identifiers

NCT00868270

HY55-08

Details and patient eligibility

About

The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.

Enrollment: 35 estimated patients

Sex: All

Ages: Under 7 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children aged 0-7
• First episode febrile UTI

Exclusion criteria

• Recurrent UTI

Trial design

35 participants in 1 patient group

Children with UTIs