Urinary Excretion of Anthocyanins During Long Term Blueberry Feeding

Atlantic Food and Horticulture Research Center

Status: Completed

Conditions: Bioavailability

Treatments: Other: Blueberry Juice

Study type: Interventional

Funder types: Other

Identifiers

NCT01789359

BBAnthoUrine

AAFC-WBANA (Other Grant/Funding Number)

Details and patient eligibility

About

Essentially all of the published data on anthocyanin absorption in humans are from short term studies - a few days or less, most typically 24 h. However human studies demonstrating clinical effects are typically conducted for several weeks or even months. To examine how anthocyanin absorption and metabolism may be affected this study will examine urinary excretion of anthocyanins over one month, followed by a one week washout, and then one more dose of blueberry juice.

Enrollment: 17 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Provided written consent (see: Information and Consent Form)
• Fluent in English
• Complete a confidential medical questionnaire (Appendix 6)
• Able and willing to abide by the dietary restrictions as described
• Able and willing to abide by the urine collection protocols as described

Exclusion criteria

• No written consent
• No confidential medical questionnaire
• Unable to comply with diet restrictions and other study requirements

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

anthocyanin-free diet

Other group

Description:

Maintain anthocyanin-free diet throughout study. Day 1 to day 30, consume daily 250 ml single strength blueberry juice containing 229 mg anthocyanins, taken either as 1 morning dose or 1/3 dose morning, 1/3 mid-day and 1/3 evening. At d 31-38 continue anthocyanin-free diet. On d 39 consume daily dose.

Treatment:

Other: Blueberry Juice