Urinary Markers of Detrusor Overactivity in Spina Bifida Patients (BUHD-SPINA)

Rennes University Hospital

Status: Completed

Conditions: Spina Bifida; Multiple Sclerosis; Spinal Cord Injury; Overactive Bladder

Study type: Observational

Funder types: Other

Identifiers

NCT02852317

35RC14_8805

Details and patient eligibility

About

The purpose of this study is to assess diagnostic performance of urinary markers of detrusor overactivity (Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), adenosine triphosphate (ATP), Prostaglandine E2) in detected high pressure bladder un spina bifida patients.

Enrollment: 134 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Study arm:

• Spina bifida patient
• Seen consecutively in outpatient clinics
• Age > 18 years-old

Control arm:

• Patients with multiple sclerosis or spinal cord injury or overactive bladder
• Seen consecutively in urodynamics
• with lower urinary tract symptoms
• Age > 18 years-old

Exclusion criteria

• Positive urine culture
• History of urologic neoplasms
• History of interstitial cystitis

Trial design

134 participants in 4 patient groups

Spina bifida patient

Patients with multiple sclerosis

Patients with spinal cord injury

Patients with overactive bladder