Urinary NGAL and KIM-1 After ESWL

Marmara University

Status: Completed

Conditions: Urinary Stone; Renal Injury

Treatments: Other: No intervention; Other: No Interventions

Study type: Observational

Funder types: Other

Identifiers

NCT07341269

MAR.UAD.0027

Details and patient eligibility

About

The goal of this prospective observational study is to evaluate the effect of different time intervals between extracorporeal shock wave lithotripsy (ESWL) sessions on renal injury using urinary biomarkers in patients with urinary system stone disease.

The main questions it aims to answer are:

Does the interval between consecutive ESWL sessions affect the degree of renal injury?

Are urinary NGAL and KIM-1 levels reliable biomarkers for detecting ESWL-related renal damage?

What is the optimal time interval between ESWL sessions to minimize renal injury?

If there is a comparison group, researchers will compare patients undergoing ESWL with different inter-session time intervals to determine whether shorter or longer intervals are associated with higher levels of renal injury biomarkers.

Participants will:

Undergo ESWL treatment for urinary system stones

Be assigned to one of two groups based on the time interval between ESWL sessions

Provide urine samples before ESWL and after three ESWL sessions

Have urinary NGAL and KIM-1 levels measured to assess renal injury

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 18 years and older
• Patients with an indication for extracorporeal shock wave lithotripsy (SWL) for urinary system stone disease

Exclusion criteria

• Positive nitrite on urinalysis prior to SWL
• Positive urine culture prior to SWL, defined as >10⁵ CFU/mL bacterial growth
• Suspected struvite stone, based on previous or partial stone analysis
• Presence of a nephrostomy tube
• Presence of urinary diversion
• History of bleeding disorders
• Pregnancy
• Use of anticoagulant therapy
• History of cardiac arrhythmia

Trial design

50 participants in 1 patient group

Patients undergoing extracorporeal shock wave lithotripsy (SWL)

Treatment:

Other: No Interventions

Other: No intervention