Urine Adiponectin Concentration in Prediction of Contrast Induced Nephropathy

Air Force Military Medical University of People's Liberation Army

Status: Unknown

Conditions: Myocardial Ischemia

Study type: Observational

Funder types: Other

Identifiers

NCT01372891

xjyy110502

Details and patient eligibility

About

The present study is to determine the ability of urinary total adiponectin and its isoforms excretion in the prediction of contrast induced nephropathy (CIN) in the patients undergoing PCI.

Full description

Contrast induced nephropathy (CIN) is a severe complication after percutaneous coronary intervention (PCI). CIN is responsible for approximately genic renal insufficiency and is the third cause of hospital-acquired renal failure and the injury of endothelial of renal tubule is responsible for the CIN. However markers reliably identifying CIN in the patients undergoing PCI are rare. Adiponectin is a 30-kDa adipocyte-derived vasoactive peptide closely linked to components of the metabolic syndrome. Recent study demonstrates that the quantification of urinary adiponectin excretion appears to be an independent indicator of vascular damage potentially identifying an increased risk for vascular events. Therefore, the investigators presume that the adiponectin excretion may predict the incidence of the CIN. The present study is to determine the ability of urinary total adiponectin and its isoforms excretion in the prediction of CIN in the patients undergoing PCI.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients > 18 of age who are undergoing elective PCI and are able to give informed consent are eligible for study.

Exclusion criteria

• The end-stage renal failure
• The patients who are relieving dialysis

Trial design

400 participants in 1 patient group

Patients underging PCI