Urine and Ultrasound Screening for Kidney Disease in Children

Fudan University

Status: Enrolling

Conditions: Child, Only; Kidney Diseases; Diagnostic Techniques; Urinalysis; Ultrasound

Treatments: Other: Urine and Ultrasound Screening

Study type: Interventional

Funder types: Other

Identifiers

NCT06018831

2021YFC2500202

Details and patient eligibility

About

The aim of this study is to early detect kidney disease in the natural population cohort of children by urine and ultrasound screening, to assist in the precise prevention and treatment of children's kidney disease, and to establish a risk prediction system for children's kidney disease. About 10,000 children called KunQi Cohort are born in Jiangsu Province(8,000 in Kunshan and 2,000 in Qidong) and about 3,000 born in Shanghai. Through the project, child who is found with abnormal urine or ultrasound result will be referred to Children's Hospital of Fudan University to get further examination and treatment.

Full description

Chronic kidney disease (CKD) often has an insidious onset. Early detection of CKD and more aggressive treatment and monitoring of high-risk CKD patients at risk of progression are the consensus of current medical practice. However, there is currently no CKD risk prediction system for the Chinese population, especially children. The main goal of this project is to establish a risk prediction system for children's kidney disease, and to assist in the precise prevention and treatment of children's kidney disease. The project is based on the "urine and ultrasound screening" strategy that has been carried out for more than ten years in Shanghai, using a non-invasive and effective screening method in the natural population cohort of children, in order to detect kidney disease in the early stage.

Enrollment: 13,000 estimated patients

Sex: All

Ages: Under 6 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All consecutive live newborn infants(regardless of physical condition)
• Complete at least 3 years of follow-up

Exclusion criteria

• Declining the screening
• Missing

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13,000 participants in 1 patient group

Urine and Ultrasound Screening

Experimental group

Description:

About 10,000 children called KunQi Cohort are born in Jiangsu Province(8,000 in Kunshan and 2,000 in Qidong) and about 3,000 born in Shanghai. Children will receive urine and ultrasound screening in 0-3 months ,and complete 3 to 6 years of follow-up( at least one type screening every year)

Treatment:

Other: Urine and Ultrasound Screening