Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex

TC Erciyes University

Status

Completed

Conditions

Premature Ventricular Contraction

Treatments

Diagnostic Test: 24 hours urine levels metanephrine and normetanephrine

Study type

Observational

Funder types

Other

Identifiers

NCT03447002

ErciyesU

Details and patient eligibility

About

Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Full description

Premature ventricular complex is a very frequent arrhythmia. Suggested mechanisms for PVCs are reentry, triggered activity, and enhanced automaticity. Enhanced automaticity process is the underlying mechanism for arrhythmias due to excess catecholamines. Catecholamines may increase in patients with PVC. Half-lives of catecholamines are very short and rather changeable. Therefore, 24 hours urine levels of catecholamines are the more sensitive than plasma levels. Metabolites of catecholamines are metanephrine and normetanephrine. Our aim is to measure 24 hours urine levels of metanephrine and normetanephrine.

Enrollment

100 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria