Urine Proteome of Surgical Patients and Healthy Volunteers (UP)

The Washington University

Status: Completed

Conditions: Renal Cell Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01538823

201202051

Details and patient eligibility

About

The purpose of this study is to define early urinary biomarkers for diagnosis and prognosis of Renal Cell Carcinoma (RCC) with subsequent development of reliable, cost-effective, screening techniques.

Enrollment: 664 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years and older
• Planned procedure with presumptive diagnosis of RCC, bladder or prostate cancer OR control patient undergoing non-urological surgery OR normal healthy volunteer OR post surgical patient with a diagnosis of RCC and under surveillance for reoccurrence of RCC or treatment of metastatic RCC
• Signed, informed consent

Exclusion criteria

• Patients on dialysis

Trial design

664 participants in 7 patient groups

Group 1

Description:

Enrollment of surgical patients at Barnes Jewish Hospital (BJH) with a presumptive diagnosis of RCC and planned nephrectomy or partial nephrectomy.

Group 2

Description:

Surgical patients at BJH with non urological cancers

Group 3

Description:

Surgical patients at BJH with a presumptive diagnosis of RCC and planned nephrectomy or partial nephrectomy

Group 4

Description:

Surgical patients at BJH with non urological cancers

Group 5

Description:

Healthy volunteers with no history of cancer or renal disease

Group 6

Description:

Patients at BJH/Washington University School of Medicine under post procedure surveillance for RCC recurrence and patients under treatment for metastatic disease.

Group 7

Description:

Patients with a presumptive diagnosis of bladder cancer or prostate cancer