Urolithin A Supplementation to Boost Immune Health

Amazentis

Status

Completed

Conditions

Aging

Treatments

Dietary Supplement: Softgel containing placebo

Dietary Supplement: Softgel containing 250mg of Urolithin A (Mitopure)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT05735886

22.03.AMZ

Details and patient eligibility

About

To show that a natural mitophagy activator (Urolithin A) given orally can modulate mitochondrial activity in immune cells in healthy adults and this results in better immune function

Enrollment

50 patients

Sex

All

Ages

45 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy Adults that do not suffer from an uncontrolled chronic medical condition that carries metabolic consequences (as assessed by the study physician)

BMI<35kg/m2
Provide informed consent
Adults aged 45-70 years, both genders
Subjects who have not received any systemic immunosuppression in the past 6 months
Subjects with any medical condition that in the opinion of the investigators would compromise the study outcome or the safety of the research participant

Exclusion criteria

Subject has any concurrent medical, orthopedic, or psychiatric condition that, in the opinion of the Investigator, would compromise his/her ability to comply with the study requirements;

Clinically significant abnormal laboratory results at screening
Participation in a clinical research trial within 30 days prior to randomization
Allergy or sensitivity to study ingredients
Individuals who are cognitively impaired and/or who are unable to give informed consent
Any condition which in the Investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject
Current gastrointestinal condition which could interfere with the study (e.g. IBS/IBD, diarrhea, acid reflux disease, dysphagia etc.);
Excessive alcohol consumption and/or a smoker
Concomitant use of statins
Engage in regular moderate or vigorous physically activities (i.e. Category 3 as per the IPAQ activity classification)
Concomitant use of corticosteroids, antibiotics, any anabolic steroid, creatine, whey protein supplements, casein or branched-chain amino acids (BCAAs), immune-boosting(Vitamin C, Zinc) or mitochondrial (COQ10, NAD+) supplements within 45 days prior to screening