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US and MRI of the Forefoot: Intermetatarsal Bursitis or Morton's Neuroma

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Rigshospitalet

Status

Invitation-only

Conditions

Morton Neuroma
Intermetatarsal Bursitis
Intermetatarsal Neuroma

Treatments

Diagnostic Test: MRI with contrast
Diagnostic Test: Ultrasound

Study type

Interventional

Funder types

Other

Identifiers

NCT05685160
H-20067346

Details and patient eligibility

About

The aim of this study is to investigate the incidence of intermetatarsal bursitis and Morton's neuroma in patients with metatarsalgia (i.e. pain in the forefoot) and control subjects by diagnostic imaging with ultrasound and MRI.

Full description

In a group of patients with intermetatarsal pain found by an orthopedic surgeon, the investigators want to assess the incidences of intermetatarsal bursitis and Morton's neuroma, using diagnostic imaging; ultrasound and MRI.

The hypothesis is, that intermetatarsal bursitis is an overlooked diagnosis in patients with metatarsalgia. As a result of sparse literature and lack of knowledge about this condition with symptoms mimicking Morton's neuroma, a part of patients diagnosed with Morton's neuroma, suffers from intermetatarsal bursitis instead.

Additionally, the investigators want to evaluate the clinical sign opening toes.

Based on clinical photos of the feet, the investigators want to document the presence of opening toes and investigate if there is a correlation with either intermetatarsal bursitis and/or Morton's neuroma.

Enrollment

75 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age > 18 years
  • Pain in an intermetatarsal space (patient group)

Exclusion criteria

  • Age <18 years
  • Open wounds or ongoing infection in the forefoot at the time of examination
  • Persons with contraindications to participate in MRI scan
  • Persons with a history of significant trauma in the forefoot, e.g. any fracture or previous surgeries in the forefoot
  • Persons who have previously received treatment for Morton's neuroma in the same foot, e.g. injection (within 6 months) or operation (anytime)
  • Persons with severely impaired renal function (GFR <30 ml/min)
  • Persons with a systemic inflammatory condition like rheumatoid arthritis, due to clinically silent intermetatarsal bursitis in this group (control group)

Trial design

Primary purpose

Diagnostic

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

75 participants in 2 patient groups

Patient group
Experimental group
Description:
Patients with intermetatarsal pain have ultrasound and MRI done
Treatment:
Diagnostic Test: Ultrasound
Diagnostic Test: MRI with contrast
Control group
Active Comparator group
Description:
Healthy individuals (no forefoot pain) undergo ultrasound and MRI scan of the forefoot.
Treatment:
Diagnostic Test: Ultrasound
Diagnostic Test: MRI with contrast

Trial contacts and locations

1

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Central trial contact

Sif B Larsen, MD

Data sourced from clinicaltrials.gov

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