Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy

King Abdul Aziz Specialist Hospital

Status: Completed

Conditions: to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs

Treatments: Drug: isopropyl alcohol 70% inhalation; Procedure: laparoscopic appendectomy; Drug: Ondansetron

Study type: Observational

Funder types: NETWORK

Identifiers

NCT04403191

ICU-10-20

Details and patient eligibility

About

To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.

Full description

This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.

Enrollment: 240 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

postoperative nausea and vomiting

Exclusion criteria

systemic disease as diabetes or hypertension local gastric diseases

Trial design

240 participants in 3 patient groups

Group A

Description:

received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours

Treatment:

Procedure: laparoscopic appendectomy

Drug: Ondansetron

Group B

Description:

received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours

Treatment:

Procedure: laparoscopic appendectomy

Drug: isopropyl alcohol 70% inhalation

Group C

Description:

received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours.

Treatment:

Procedure: laparoscopic appendectomy