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Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy

K

King Abdul Aziz Specialist Hospital

Status

Completed

Conditions

to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs

Treatments

Drug: isopropyl alcohol 70% inhalation
Procedure: laparoscopic appendectomy
Drug: Ondansetron

Study type

Observational

Funder types

NETWORK

Identifiers

NCT04403191
ICU-10-20

Details and patient eligibility

About

To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.

Full description

This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.

Enrollment

240 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

postoperative nausea and vomiting

Exclusion criteria

systemic disease as diabetes or hypertension local gastric diseases

Trial design

240 participants in 3 patient groups

Group A
Description:
received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours
Treatment:
Procedure: laparoscopic appendectomy
Drug: Ondansetron
Group B
Description:
received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours
Treatment:
Procedure: laparoscopic appendectomy
Drug: isopropyl alcohol 70% inhalation
Group C
Description:
received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours.
Treatment:
Procedure: laparoscopic appendectomy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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