Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans

The University of Texas System (UT)

Status: Active, not recruiting

Conditions: Neural Dynamics of the Acquisition and Retention of Fear Learning and Active Avoidance Learning

Treatments: Behavioral: Conditioning and active avoidance paradigm (CAAP)

Study type: Interventional

Funder types: Other

Identifiers

NCT06240052

HSC-MS-23-0841

Details and patient eligibility

About

The purpose of this study is to examine which event-related potentials (ERPs) and event-related oscillations (EROs) are associated with fear conditioning, avoidance learning, and memory recall for fear and avoidance, where are the source generators of the observed scalp EEG activity, the impact of fear and avoidance learning on the decision to avoid or not to avoid conditioned stimuli , to examine the large-scale functional connectivity across distributed brain regions across experimental phases, and to examine whether spontaneous EEG data during resting-state correlate with the EEG measures during experimental tasks.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Willing and able to provide informed consent.

Exclusion criteria

• History of neurologic disease
• History of seizure or significant head trauma/loss of consciousness
• Significant serious psychiatric diagnosis
• Significant suicidal ideation or behaviors
• High risk of adverse emotional or behavioral reaction, and/or an inability to understand study procedures or the informed consent process, based on investigator/clinician clinical evaluation

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

Conditioning and active avoidance paradigm (CAAP)

Experimental group

Treatment:

Behavioral: Conditioning and active avoidance paradigm (CAAP)