Use of 2-octylcyanoacrylate With Full-thickness Skin Grafts

University of California (UC) Davis

Status: Completed

Conditions: Wound Closure Techniques

Treatments: Procedure: Wound Closure with 5-0 Vicryl Sutures; Procedure: Wound Closure with 2-octylcyanoacrylate

Study type: Interventional

Funder types: Other

Identifiers

NCT02550574

773443

Details and patient eligibility

About

The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of cutaneous surgery wounds with full-thickness skin grafts improves scar cosmesis compared to wound closure with sutures.

Full description

The purpose of this study is to determine whether the use of 2-octylcyanoacrylate during repair of cutaneous surgery wounds with full-thickness skin grafts improves scar cosmesis compared to wound closure with sutures. Our aims are to compare outcomes using a split wound model, where half of the wound is treated with 2-octylcyanoacrylate and the other half is repaired with sutures, per the standard of care. Three-months post-surgery, the scar will be measured via the physician observer scar assessment scale, a validated scar instrument. Our hypothesis is that 2-octylcyanoacrylate will result in cosmetically superior wound outcomes.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Over 18 years of age
• Able to give informed consent themselves
• Patient scheduled for cutaneous surgical procedure with predicted closure with full-thickness skin graft
• Willing to return for follow-up visits

Exclusion criteria

• Mentally handicapped
• Unable to understand written and oral English
• Incarceration
• Under 18 years of age
• Pregnant Women
• Patients on systemic steroid therapies
• Patients with Marfans
• Patients with allergies to 2-octylcyanoacrylate

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Wound closure with 2-octylcyanoacrylate

Experimental group

Description:

One side of the patient's wound defect will be assigned to wound closure with 2-octylcyanoacrylate liquid bonding agent).

Treatment:

Procedure: Wound Closure with 2-octylcyanoacrylate

Procedure: Wound Closure with 5-0 Vicryl Sutures

Wound closure with 5-0 vicryl sutures

Active Comparator group

Description:

One side of the patient's wound defect will be assigned to wound closure with 5-0 vicryl sutures.

Treatment:

Procedure: Wound Closure with 2-octylcyanoacrylate

Procedure: Wound Closure with 5-0 Vicryl Sutures