Use of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes (UTROPIA)

Hennepin Healthcare

Status: Completed

Conditions: Troponin; Acute Coronary Syndrome; Myocardial Infarction

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02060760

HSR 13-3690

Details and patient eligibility

About

Hypothesis: High sensitivity cTnI assays will have improved diagnostic accuracy for type 1 MI compared to contemporary cTnI assays.

The primary objective of the study is to determine the performance of a high sensitivity cardiac troponin I (hs-cTnI) assay compared to a contemporary cTnI assay for the diagnostic accuracy of type 1 acute myocardial infarction (AMI).

The diagnostic performance of Abbott's hs-cTnI assay will be evaluated. Investigators will assess the assay's ability to diagnose AMI earlier and to rule out AMI earlier. The sensitivity, specificity, positive predictive value and negative predictive value of the hs-cTnI assay will be evaluated with both a universal cut off as well as with gender and potentially age derived 99th percentile upper reference limits (URL).

Investigators will evaluate delta hs-cTnI values (pre-specified absolute concentration and percent changes over time) for their ability to contribute to the negative predictive value and hence potentially lead to an earlier rule out of AMI (improved specificity). Additionally, investigators will assess delta changes of the hs-cTnI assay for their potential contribution to the clinical differentiation of type 1 and type 2 (supply demand mismatch) MIs.

Lastly, investigators will compare the diagnosis of AMI based on the currently used contemporary assay to the hs-assay, to assess both the incidence of AMI as well as for the time to diagnosis.

Enrollment: 1,927 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Two or more cTnI values ordered for any clinical indication with specimen available for hs cTnI assay
• 18 years of age or older
• EKG done on admission / presentation
• Agree to research disclosure

Exclusion criteria

• Admission through any venue other an emergency department
• Repeat admission for the same patient, only primary admission will be assessed
• Pregnancy

Trial design

1,927 participants in 1 patient group

UTROPIA study cohort

Description:

At least two cTnI data points available (including baseline) with blood samples available for hs-cTnI testing. No intervention.