Use of Atropine in Tredmill Stress Testing

HaEmek Medical Center, Israel

Status and phase: Completed; Phase 3

Conditions: Chest Pain

Treatments: Drug: Atropine

Study type: Interventional

Funder types: Other

Identifiers

NCT00623207

07-0139 EMC

Details and patient eligibility

About

The aim of this study is to evaluate the Safety and feasibility of atropine added during treadmill stress testing in patients with chronotropic incompetence or poor exercise capacity.

Our hypothesis is that we can increase heart rate by using atropin in these patients, so we will achieve more conclusive results.

Enrollment: 103 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with chest pain without evidence of ischemia eligible for exercise test.
• Age> 18 years old

Exclusion criteria

Absolute:

• Patients with LBBB
• Unstable Angina
• Recent Myocardial Infarction
• Un controlled Arrythmia
• Congestive heart faliure
• Severe symptomatic valvular heart disease
• Acute Pulmonary Embolism
• Acute perimyocarditis
• Acute aortic dissection

Relative:

• Lt main stenosis
• Severe hypertention (Systolic> 200 mmHg; Diastolic > 100 mmHg)
• Cardiomyopathy
• Obstructiove abnormalities
• Psychiatric disorders
• High degree AV Block

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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103 participants in 2 patient groups, including a placebo group

1

Placebo Comparator group

Description:

Pateints who achieve target haert rate or conclusive test will not be given Atropine

Treatment:

Drug: Atropine

2

Active Comparator group

Description:

Patients who won't achieve tarhet heart rate or conclusive results will be given Atropine

Treatment:

Drug: Atropine