Use of Botox to Treat Scrotal Pain

Mount Sinai Hospital, Canada

Status and phase

Completed

Phase 1

Conditions

Scrotal Pain

Treatments

Drug: Botox

Study type

Interventional

Funder types

Other

Identifiers

NCT01832194

CAN_BTX

Details and patient eligibility

About

There are no previous reports on the use of Onabotulinum Toxin A to treat men with scrotal pain that we found published. We propose a pilot study to use Botox to block the testicular nerves on a group of 15 men with chronic scrotal pain who have failed the standard medical therapy. The men must have had temporary relief from a testicular cord block using marcaine. Before and 1 month, 3 months and 6 months after the Onabotulinum Toxin A injection, the men would be asked to fill in visual analog scales for pain, a quality of life assessment, a depression index (MDI) and Chronic Epididymitis Symptom Index (CESI). They will also be subject to sensory testing of the scrotum before, after 1 month, 3 moths and 6 months.

Enrollment

20 patients

Sex

Male

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18-65
Have nociceptive scrotal pain,
Have no identifiable, reversible causes for the scrotal pain
Have failed standard medical therapy
Have responded temporarily to cord blocks

Exclusion criteria

Are interested in trying to conceive with their partners in the next 6 months,
Have any local infection near the site of the injections,
Have had an allergic reaction to Botox in the past,
Are unable to provide informed consent
Have a history of motor neuron disease or neurogenic bladder
Who have hemostatic disorder or who are taking aspirin, Coumadin (warfarin), Xarelto (rivaroxaban) or other blood thinners