Use of Brain Oxygen Tension Level and Cleaved-tau Protein to Detect Vasospasm After SAH

University of Wisconsin (UW)

Status: Terminated

Conditions: Subarachnoid Hemorrhage; Cerebral Vasospasm

Treatments: Device: Licox Brain Oxygen Monitor; Other: CSF; Other: Whole blood

Study type: Observational

Funder types: Other

Identifiers

NCT00582868

H-2006-0421

Details and patient eligibility

About

The purpose of this study is to investigate if brain oxygen levels, levels of a specific protein in the cerebrospinal fluid and blood (Cleaved-tau protein), and brain blood flow can predict spasm of brain blood vessels after bleeding in the brain from a ruptured aneurysm.

Full description

Rupture of a cerebral aneurysm causes subarachnoid hemorrhage (SAH). Blood in the subarachnoid space of the brain can cause irritation of the cerebral blood vessels, leading to constriction of these vessels, a phenomenon known.as vasospasm. Cerebral vasospasm can cause stroke and possibly death. Of all the patients with SAH, approximately 20-40% will suffer from clinical vasospasm and more than 60% of those patients will never get back to their previous functional status. Tools to identify early vasospasm and thus early treatment could greatly decrease the morbidity and mortality following SAH.

Cleaved tau protein is a neuronal marker that has been detected in blood and CSF of stroke patients early in its time course. Since vasospasm can lead to stroke, the purpose of this project is to determine whether increase in cleaved tau protein in blood and/or CSF can predict early stroke from vasospasm. Changes in brain oxygen tension measured by a brain tissue oxygen monitor and cerebral blood flow measured by CT perfusion will be correlated with cleaved tau protein levels and clinical status. Utilizing statistical analysis the levels of Cleaved tau protein, brain oxygen and blood flow during hospitalization will be correlated with patient outcome. Through this study we hope to identify increase in cleaved tau protein and decrease in cerebral blood flow and oxygenation as predictors of early vasospasm. Early detection and treatment of vasospasm could decrease the stroke rate in SAH patients and therefore be of great benefit to society.

Enrollment: 10 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with subarachnoid hemorrhage
• Patients with external ventricular drains

Exclusion criteria

• Patients in whom consent is not attainable

Trial design

10 participants in 1 patient group

Hemorrhage

Description:

Patients having experienced subarachnoid hemorrhage and have in place a ventriculostomy

Treatment:

Device: Licox Brain Oxygen Monitor

Other: Whole blood

Other: CSF