Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI (GlioCEST)

Institut de cancérologie Strasbourg Europe

Status: Enrolling

Conditions: Brain Metastases; Glioma

Treatments: Other: Additional CEST sequences during PET/MRI exam

Study type: Interventional

Funder types: Other

Identifiers

NCT05464992

2022-A00910-43 (Other Identifier)

2022-005

Details and patient eligibility

About

Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast. However, assessing the presence of other molecules than water in tissues is also of great clinical interest to probe metabolites related to physiological body function and pathological conditions.

Chemical exchange saturation transfer (CEST) allow to overcome some limitations of proton magnetic resonance spectroscopy (1H-MRS) by exploiting chemical properties of the targeted molecule through a continuous process of re-saturation and exchange, and thus detecting it with increased sensitivity, from two orders of magnitude. Moreover, CEST technique is based on imaging sequences and can therefore benefit from well-known fast acquisition strategies, as well as improved spatial resolution.

Full description

For this study the investigators propose to include an additional CEST sequence in standard PET/MRI exam in order to obtain a cartography with biochemical informations from tissues in patients with glioma or brain metastases.

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients admitted to the Nuclear Medicine and Molecular Imaging department of ICANS (Institut de cancérologie strasbourg Europe) for a PET/MRI exam dedicated to:

• Preoperative evaluation of a cerebral expansion lesion
• Evaluation of glioma recurrences
• Evaluation of brain metastases
• Evaluation of recurrence of metastases

Exclusion criteria

• Contraindication to the realization of an MRI
• Minor or patients placed under guardianship or supervision
• Patients deprived of liberty
• Patients placed under judicial protection
• Patients that are not able to express their consent
• Pregnant and breastfeeding women

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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800 participants in 1 patient group

Patients with glioma or brain metastases

Other group

Treatment:

Other: Additional CEST sequences during PET/MRI exam