Use of Clarithromycin in Mustard-Induced Bronchiolitis

Baqiyatallah Medical Sciences University

Status and phase

Completed

Phase 3

Conditions

Bronchiolitis Obliterans

Acute Obliterating Bronchiolitis

Treatments

Drug: Clarithromycin

Study type

Interventional

Funder types

Other

Identifiers

NCT00381147

S-340-14-6-1-PU-11

Details and patient eligibility

About

We looked for the effectiveness of low-dose long-term prescription of clarithromycin in mustard-induced chronic pulmonary lesions, especially bronchiolitis obliterans

Sex

Male

Volunteers

No Healthy Volunteers

Inclusion criteria

His/her own will to participate
Documented chemical exposure
Clinical, spirometric and radiological findings were compatible with BO on High Resolution Computed Tomography (HRCT)

Exclusion criteria

any drug reactions during the trial
history of sensitivity to macrolides
diarrhea, gray stool, jaundice, eosinophilia, acute cholestatic hepatitis, pruritis, dark urine, abdominal pain, osteomatosis, depression, taste change, behavioural changes, early fatigue, odynophagia, glossitis , dizziness
co-adminstration of: terfenadine, theophylline, carbamazepine, ergotamine, dihydroergotamine, warfarin, cisapride, digoxin, triazolam, phenytoin, steroids, any immunosuppressive, any systemic antibiotics
using drugs that he/she cannot discontinue
using drugs with potential interaction
subject will to exit from the trial
history of lobe resection of lung
history of exacerbation in the last month prior to the beginning of trial
continuous need to oxygen
use of corticosteroids in last week prior to the trial beginning
Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic
exacerbating of subjects
creatinine srum level more than normal
increasing ALT, AST levels
total bilirubin more twice than normal
subjects who did not use their drugs properly