Use of Copeptin in Diabetes Insipidus

University Hospital Basel

Status: Completed

Conditions: Primary Polydipsia; Diabetes Insipidus

Treatments: Other: Water deprivation test; Other: Hypertonic saline infusion

Study type: Observational

Funder types: Other

Identifiers

NCT01940614

CODDI2013

Details and patient eligibility

About

Prospective evaluation of the novel biomarker copeptin in the differential diagnosis of diabetes insipidus against the standard diagnostic test methods.

Full description

Purpose of this study is to compare the overall diagnostic accuracy of the three following diagnostic test procedures in diabetes insipidus (central, nephrogenic) and primary polydipsia: a) classical water deprivation test alone, b) classical water deprivation test plus plasma copeptin cut-off levels, c) hypertonic saline infusion test plus plasma copeptin measurement.

The investigators hypothesize that firstly b) and c) is better as a). Secondly the investigators hypothesize that c) is non-inferior to b).

Enrollment: 156 patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Polyuria or/and Polydipsia or/and therapy with synthetic adenovirus proteinase (AVP) derivate
• Urine osmolality <800mOsm/kgH20

Exclusion criteria

• Polyuria due to diabetes mellitus
• Hypokalemia
• Hyperkalemia (>5mmol/l)
• Hypercalcemia
• Kidney disease (min.: glomerular filtration rate (GFR) 60ml/min/1.73m2)
• Pregnancy
• Hyponatremia >135mmol/L
• Hypernatremia >145mmol/L
• Hypo- or hypervolemia
• uncorrected adrenal or thyroidal deficiency
• Cardia failure
• Epilepsia
• Uncontrolled hypertension