Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients

Johns Hopkins University

Status and phase: Withdrawn; Phase 2

Conditions: Familial Adenomatous Polyposis

Treatments: Drug: curcumin

Study type: Interventional

Funder types: Other

Identifiers

NCT00248053

05-04-12-04

Details and patient eligibility

About

The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Familial adenomatous polyposis
• 18 years of age or older
• 5 or more adenomas of colorectum or ileum

Exclusion criteria

• Female patient of child bearing age not on effective birth control pills
• Pregnant women
• White blood cell (WBC) count less than 4000
• Platelets (Plts) less than 100,000
• Blood urea nitrogen (BUN) greater than 25
• Creatine greater than 1.5
• Patients unable to stop non-steroidal anti-inflammatory drugs (NSAIDs) during duration of trial
• Malignancy
• Patient with active bacterial infections of gastroesophageal reflux disease or peptic ulcer disease
• Patient on warfarin or anti-platelet drugs

Trial design

0 participants in 1 patient group

Lower GI

Other group

Treatment:

Drug: curcumin