Use of Dexamethasone in Uterine Artery Embolization

Yonsei University

Status: Completed

Conditions: Uterine Myoma; Adenomyosis

Treatments: Drug: Normal saline; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02056717

4-2013-0863

Details and patient eligibility

About

The primary purpose of this study is to investigate the effects of dexamethasone on inflammatory reactions after uterine artery embolization. The secondary purpose of this study it to investigate the effects of dexamethasone on postembolization syndrome (severe pain, nasea and vomiting).

Enrollment: 64 patients

Sex: Female

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Uterine artery embolization due to multiple myoma or adenomyosis

Exclusion criteria

• Diabetic mellitus
• Steroid administration
• Liver or kidney dysfuntion
• High baseline CRP or leukocytosis (>11,000/μL )
• Drug allergy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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64 participants in 2 patient groups, including a placebo group

Dexamethasone group

Experimental group

Treatment:

Drug: Dexamethasone

Control group

Placebo Comparator group

Treatment:

Drug: Normal saline