Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management

C

Capital Medical University

Status

Unknown

Conditions

Diuretic Abuse

Treatments

Drug: Furosemid hydrochlorothiazide

Study type

Interventional

Funder types

Other

Identifiers

NCT04182854
YN2017QN15

Details and patient eligibility

About

Background.The objective of the present study is to verify whether using diuretics will improve either blood pressure or fluid overload in maintenance hemodialysis patients with residual diuresis kidney function.

Full description

Methods.46 maintenance hemodialysis patients will be given three stages of diuretic intervention: 100mg furosemide every day for 1 month, 200mg furosemide every day for 1 month, and 100mg furosemide combined with 25mg hydrochlorothiazide every day for 1 month. The 24-hour urine volume, 24-hour urine sodium, 24-hour urine potassium, blood pressure, OH(overhydration) and dry weight will be collected. OH will be measured by bioelectrical impedance.

Enrollment

46 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • maintenance hemodialysis patient
  • unrine volume more than 100ml.

Exclusion criteria

  • myocardial infarction;
  • unrine volume less than 100ml.

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

46 participants in 1 patient group

diuretics
Experimental group
Treatment:
Drug: Furosemid hydrochlorothiazide

Trial contacts and locations

0

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Central trial contact

zhoucang Zhang, Master; Yunfei Ding, Master

Data sourced from clinicaltrials.gov

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