Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management

Capital Medical University

Status: Unknown

Conditions: Diuretic Abuse

Treatments: Drug: Furosemid hydrochlorothiazide

Study type: Interventional

Funder types: Other

Identifiers

NCT04182854

YN2017QN15

Details and patient eligibility

About

Background.The objective of the present study is to verify whether using diuretics will improve either blood pressure or fluid overload in maintenance hemodialysis patients with residual diuresis kidney function.

Full description

Methods.46 maintenance hemodialysis patients will be given three stages of diuretic intervention: 100mg furosemide every day for 1 month, 200mg furosemide every day for 1 month, and 100mg furosemide combined with 25mg hydrochlorothiazide every day for 1 month. The 24-hour urine volume, 24-hour urine sodium, 24-hour urine potassium, blood pressure, OH(overhydration) and dry weight will be collected. OH will be measured by bioelectrical impedance.

Enrollment: 46 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• maintenance hemodialysis patient
• unrine volume more than 100ml.

Exclusion criteria

• myocardial infarction;
• unrine volume less than 100ml.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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46 participants in 1 patient group

diuretics

Experimental group

Treatment:

Drug: Furosemid hydrochlorothiazide