Use of Fluorescein Dye for the Removal of Brain Tumors

University of Pittsburgh

Status: Completed

Conditions: Brain Neoplasms

Treatments: Drug: Fluorescein

Study type: Observational

Funder types: Other

Identifiers

NCT02389530

PRO14100616

Details and patient eligibility

About

Fluorescein is a dye agent that can be injected through an intravenous line. It has been shown to help tell the difference between brain tumor tissue and normal brain tissue when it is used together with a specialized filter on a microscope in the operating room. The investigators plan to study the use of fluorescein in the removal of brain tumors at a low dose.

Enrollment: 91 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age of 18 or greater
2. Plan for elective removal of a brain tumor at UPMC Shadyside with either Dr. Engh or Dr. Amankulor.

Exclusion criteria

1. History of adverse reaction to fluorescein.
2. Emergent surgical procedure (consent not feasible).
3. Creatinine of > 2.0 (drug is excreted renally).
4. Known ongoing pregnancy.

Trial design

91 participants in 1 patient group

interventional group

Description:

All participants will receive the study intervention, intravenous administration of fluorescein dye prior to brain tumor removal.

Treatment:

Drug: Fluorescein