Use of High Intensity Interval Training as a Strategy to Minimize the Insulin Resistance Observed in Sleep Deprivation (HIIT)

Federal University of São Paulo

Status: Unknown

Conditions: Insulin Resistance; Sleep Deprivation

Treatments: Other: High Intensity Interval Training

Study type: Interventional

Funder types: Other

Identifiers

NCT02125656

475074/2011-4

Details and patient eligibility

About

Sleep is an essential biological process for life and great value to functions such as learning, memory processing , cell and brain repair. Recently, new evidence points to the relationship between lack of sleep and carbohydrate metabolism , establishing a framework for insulin resistance observed in studies with restriction and sleep deprivation on several nights and in a single night . To reverse this process , one of the most effective strategies is physical exercise and part listed in the literature as a non-pharmacological tool for prevention and health promotion , as well as in the treatment of some diseases . However , the pace of modern society causes people to practice less physical exercise , lack of time being the main reason . In this scenario, the High Intensity Interval Training ( HIIT ) emerges as a powerful strategy that induces major changes optimizing the time spent on such activity. Considering the benefits of this mode , the purpose of this study is to investigate the effects of high-intensity interval training in the context of insulin resistance observed during sleep deprivation. Will be recruited 20 male volunteers, aged between 18 and 35 years old, healthy, with normal sleep duration equivalent to 7-8 hours / night, not smoking and regular eating habits. They will be submitted to a protocol of 6 sessions of high-intensity interval training for two weeks, and since the end period, sleep normally, or be deprived of sleep for 24 hours. Biochemical (thyroid hormones, cortisol, glucagon, free fatty acid, cholesterol, glucose and insulin) will be undertaken as well as evaluation of body composition by plethysmography, basal metabolic rate by indirect calorimetry and insulin sensitivity through Oral Glucose Tolerance Test (OGTT) before and after the training period.

Enrollment: 15 estimated patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Recreationally Active
• Eutrophic
• Sleep Duration about 7-8 hours

Exclusion criteria

• No Smoking
• Without Sleep disorders
• Nondiabetic

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 4 patient groups

Regular Sleep

No Intervention group

Description:

A single night of regular sleep

Sleep Deprivation

No Intervention group

Description:

A single night of sleep deprivation

HIIT + Regular Sleep

Experimental group

Description:

2 weeks of HIIT and after a single night of regular sleep.

Treatment:

Other: High Intensity Interval Training

HIIT + Sleep Deprivation

Experimental group

Description:

2 weeks of HIIT and after a single night of sleep deprivation

Treatment:

Other: High Intensity Interval Training