Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia

Lund University

Status: Completed

Conditions: Human Papillomavirus Infection; Cervical Intraepithelial Neoplasia

Study type: Observational

Funder types: Other

Identifiers

NCT00931190

95-240

Details and patient eligibility

About

The objectives are to evaluate the effectiveness of treatment of cervical intraepithelial neoplasia (CIN) by loop electrosurgical excision procedure using persistence of human papillomavirus (HPV) as outcome, and to perform a long-term follow-up on the ability of HPV testing, as compared to cytology, to predict recurrence of high-grade CIN.

Full description

Cervical samples for human papillomavirus (HPV) DNA analysis and cytological analysis were obtained from women with abnormal smears referred to Umeå university hospital, Sweden, for treatment with conization. These women were scheduled for HPV DNA testing and Pap smears before and 3, 6, 12, 24 and 36 months after treatment. The HPV DNA testing was performed with a PCR-based genotyping method.

Enrollment: 195 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Referral to Umeå university hospital for treatment due to abnormal Pap smear.

Exclusion criteria

• Lack of informed consent.