Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human

Federal University of Minas Gerais

Status and phase: Completed; Phase 2; Phase 1

Conditions: Alveolar Bone Loss

Treatments: Drug: hyaluronic acid; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02709525

CAAE: 0328.0.203.000-10

Details and patient eligibility

About

The aim of this study is to evaluate the effects of hyaluronic acid (HA) on bone healing in human dental sockets.

Enrollment: 16 patients

Sex: All

Ages: 14 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Orthodontic need for bilateral extraction of lower first premolars

Exclusion criteria

• Alcoholism, smoking, drug use and abuse of drugs; Systemic diseases: uncontrolled diabetes, blood dyscrasias, kidney or heart failure and osteoporosis; clinical or radiographic signs of pathological processes in the bone;

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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16 participants in 2 patient groups, including a placebo group

hyaluronic acid

Experimental group

Description:

Immediately after the extractions, one socket was randomly filled with 1% hyaluronic acid gel.

Treatment:

Drug: hyaluronic acid

Blood clot

Placebo Comparator group

Description:

Immediately after the extractions, the other side socket was naturally filled with blood clot.

Treatment:

Other: Placebo